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Vitamin C

Vitamin C is a water-soluble vitamin. It is needed for normal growth and development.

Water-soluble vitamins dissolve in water. Leftover amounts of the vitamin leave the body through the urine. That means you need an ongoing supply of such vitamins in your diet.


Vitamin C is needed for the growth and repair of tissues in all parts of your body. It is used to:
•Form an important protein used to make skin, tendons, ligaments, and blood vessels
•Heal wounds and form scar tissue
•Repair and maintain cartilage, bones, and teeth
•Aid in the absorption of iron

Vitamin C is one of many antioxidants. Antioxidants are nutrients that block some of the damage caused by free radicals.
•Free radicals are made when your body breaks down food or when you are exposed to tobacco smoke or radiation.
•The buildup of free radicals over time is largely responsible for the aging process.
•Free radicals may play a role in cancer, heart disease, and conditions like arthritis.

The body is not able to make vitamin C on its own, and it does not store vitamin C. It is therefore important to include plenty of vitamin C-containing foods in your daily diet.

For many years, vitamin C has been a popular remedy for the common cold.
•Research shows that for most people, vitamin C supplements or vitamin C-rich foods do not reduce the risk of getting the common cold.
•However, people who take vitamin C supplements regularly might have slightly shorter colds or somewhat milder symptoms.
•Taking a vitamin C supplement after a cold starts does not appear to be helpful.

Food Sources

All fruits and vegetables contain some amount of vitamin C.

Fruits with the highest sources of vitamin C include:
•Citrus fruits and juices, such as orange and grapefruit
•Kiwi fruit
•Strawberries, raspberries, blueberries, and cranberries

Vegetables with the highest sources of vitamin C include:
•Broccoli, Brussels sprouts, and cauliflower
•Green and red peppers
•Spinach, cabbage, turnip greens, and other leafy greens
•Sweet and white potatoes
•Tomatoes and tomato juice
•Winter squash

Some cereals and other foods and beverages are fortified with vitamin C. Fortified means a vitamin or mineral has been added to the food. Check the product labels to see how much vitamin C is in the product.

Cooking vitamin C-rich foods or storing them for a long period of time can reduce the vitamin C content. Microwaving and steaming vitamin C-rich foods may reduce cooking losses. The best food sources of vitamin C are uncooked or raw fruits and vegetables. Exposure to light can also reduce vitamin C content. Choose orange juice that is sold in a carton instead of a clear bottle.

Side Effects

Serious side effects from too much vitamin C are very rare, because the body cannot store the vitamin. However, amounts greater than 2,000 mg/day are not recommended. Doses this high can lead to stomach upset and diarrhea. Large doses of vitamin C supplementation are not recommended during pregnancy. They can lead to vitamin C deficiency in the baby after delivery.

Too little vitamin C can lead to signs and symptoms of deficiency, including:

•Bleeding gums
•Decreased ability to fight infection
•Decreased wound-healing rate
•Dry and splitting hair
•Easy bruising
•Gingivitis (inflammation of the gums)
•Possible weight gain because of slowed metabolism
•Rough, dry, scaly skin
•Swollen and painful joints
•Weakened tooth enamel

A severe form of vitamin C deficiency is known as scurvy. This mainly affects older, malnourished adults.


The Recommended Dietary Allowance (RDA) for vitamins reflects how much of each vitamin most people should get each day. The RDA for vitamins may be used as goals for each person.

How much of each vitamin you need depends on your age and gender. Other factors, such as pregnancy and illnesses, are also important.

The best way to get the daily requirement of essential vitamins, including vitamin C, is to eat a balanced diet that contains a variety of foods.

Dietary Reference Intakes for vitamin C:

•0 to 6 months: 40* milligrams/day (mg/day)
•7 to 12 months: 50* mg/day

•1 to 3 years: 15 mg/day
•4 to 8 years: 25 mg/day
•9 to 13 years: 45 mg/day

•Girls 14 to 18 years: 65 mg/day
•Pregnant teens: 80 mg/day
•Breastfeeding teens: 115 mg/day
•Boys 14 to 18 years: 75 mg/day

•Men age 19 and older: 90 mg/day
•Women age 19 year and older: 75 mg/day
•Pregnant women: 85 mg/day
•Breastfeeding women: 120 mg/day

Smokers or those who are around secondhand smoke at any age should increase their daily amount of vitamin C an additional 35 mg per day.

Women who are pregnant or breastfeeding and those who smoke need higher amounts of vitamin C. Ask your health care provider what amount is best for you.

Alternative Names
Ascorbic acid; Dehydroascorbic acid


Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013: 31;1:CD000980. PMID: 23440782

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy Press, Washington, DC, 2000. PMID 25077263

Mason JB. Vitamins, trace minerals, and other micronutrients. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 225.

Salwen MJ. Vitamins and trace elements. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 26.

Update Date 2/2/2015

Updated by: Emily Wax, RD, The Brooklyn Hospital Center, Brooklyn, NY. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

High-dose vitamin C does kill cancer

High-dose vitamin C does kill cancer—but only when it’s given intravenously. It’s now just a few steps away from being approved as a safe and effective cancer treatment alongside chemotherapy and radiation.

Although researchers have tested the vitamin as a cancer therapy many times, they almost always concluded that it was ineffective—but they were guaranteeing failure by giving it orally to patients.

When it’s given intravenously, it bypasses the gut and goes directly into the bloodstream—where concentrations of the vitamin are up to 500 times higher than when it’s taken orally—and targets cancer cells, say researchers at the University of Iowa.

The therapy is now going through the approval process, and could soon be available as an alternative to chemotherapy or radiation, the two conventional cancer treatments.

It’s been proved to be effective in animal studies, and phase 1 trials have demonstrated that it’s safe and well-tolerated.

Now doctors at the university are starting to use it on patients with pancreatic cancer and lung cancer, and are measuring their progress against other patients who will continue to be given chemotherapy or radiation.

Biologist Garry Buettner, who works at the university, has worked out just why vitamin C is so effective: the vitamin breaks down quickly in the body, and generates hydrogen peroxide that kills cancer cells. “Cancer cells are much less efficient in removing hydrogen peroxide than normal cells, so cancer cells are much more prone to damage and death from a high amount of hydrogen peroxide”, he explained. “This explains how very, very high levels of vitamin C do not affect normal tissue, but can be damaging to tumour tissue.”

(Source: Redox Biology, 2016; 10: 274)

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